4-Acetoxy-DET (4-Acetoxy-N,N-diethyltryptamine), also known as ethacetin, ethylacybin or 4-AcO-DET is a psychedelic tryptamine. It was first synthesized in 1958 by Albert Hofmann in the Sandoz lab.

It is expected that the compound is quickly hydrolyzed into the free phenolic 4-HO-DET by serum esterases, but human studies concerning the metabolic fate of this drug are lacking.


4-Acetoxy-DET is orally active, and dosages of 10–25 mg are common. Effects last 4–6 hours.[2] The free base is also active when smoked in a dose range of 5–20 mg.[1] Smoking 4-acetoxy-DET greatly speeds up the onset; peak effects are experienced within 10 minutes, and are usually over within 1 hour.

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  • Product Code: 4-AcO-DET
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Tags: 4-AcO-EPT, 4-AcO-DET is a synthetic Tryptamine. Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-AcO-DET so there is a unique opportunity to study its properties.